On the hereditary character of new strong variations of weyl type theorems

Berkani and Kachad [18], [19], and Sanabria et al. [32], introduced and studied strong variations of Weyl type Theorems. In this paper, we study the behavior of these strong variations of Weyl type theorems for an operator T on a proper closed and Tinvariant subspace W ⊆ X such that T n (X) ⊆ W for some n ≥ 1, where T ∈ L(X) and X is an infinite-dimensional complex Banach space. The main purpose of this paper is to prove that for these subspaces (which generalize the case T n (X) closed for some n ≥ 0), these strong variations of Weyl type theorems are preserved from T to its restriction on W and vice-versa. As consequence of our results, we give sufficient conditions for which these strong variations of Weyl type Theorems are equivalent for two given operators. Also, some applications to multiplication operators acting on the boundary variation space BV [0, 1] are given

Turbulencia empresarial en Colombia : sector de seguros

En el año 2010, la Facultad de Administración de la Universidad del Rosario puso en marcha un proyecto de investigación donde se exploraba el fenómeno de la turbulencia empresarial. En este momento han sido publicados más de 15 documentos donde se realiza la descripción de lo ocurrido en igual número de sectores. En este número se realiza un análisis del sector asegurador, actividad empresarial que contribuye de manera significativa a la economía del país. El trabajo ha sido realizado de manera conjunta por los profesores Natalia Malaver y Hugo Rivera de la asignatura Estrategia de empresa I, con estudiantes del pregrado de la Facultad, quienes se motivaron por encontrar respuestas a la forma como algunas empresas del sector enfrentan la turbulencia sectorial. La estructura del documento incluye una breve descripción del sector; luego un análisis de la turbulencia, y un estudio sectorial realizado aplicando la metodología del Análisis Estructural de Sectores Estratégicos (AESE) desarrollada por el grupo de investigación en perdurabilidad empresarial de la Facultad de Aministración de la Universidad del Rosario

Hydrolysable Tannins and Biological Activities of Meriania hernandoi and Meriania nobilis (Melastomataceae)

A bio-guided study of leaf extracts allowed the isolation of two new macrobicyclic hydrolysable tannins, namely merianin A (1) and merianin B (2), and oct-1-en-3-yl b-xylopyranosyl-(1”-6’)-b-glucopyranoside (3) from Meriania hernandoi, in addition to 11 known compounds reported for the first time in the Meriania genus. The structures were elucidated by spectroscopic analyses including one- and two-dimensional NMR techniques and mass spectrometry. The bioactivities of the compounds were determined by measuring the DPPH radical scavenging activity and by carrying out antioxidant power assays (FRAP), etiolated wheat coleoptile assays and phytotoxicity assays on the standard target species Lycopersicum esculentum W. (tomato). Compounds 1 and 2 exhibited the best free radical scavenging activities, with FRS50 values of 2.0 and 1.9 M, respectively

Impact of endophytic colonization by entomopathogenic fungi on the behavior and life history of the tobacco peach aphid Myzus persicae var. nicotianae

Entomopathogenic fungi can adopt an endophytic lifestyle and provide protection against insect herbivores and plant pathogens. So far, most studies have focused on Beauveria bassiana to increase plant resistance against abiotic and biotic stresses, while only little is known for other entomopathogenic fungi. In this study, we investigated whether root inoculation of sweet pepper (Capsicum annuum L.) by the entomopathogenic fungi Akanthomyces muscarius ARSEF 5128 and B. bassiana ARSEF 3097 can improve resistance against the tobacco peach aphid Myzus persicae var. nicotianae. First, dual-choice experiments were performed to test the hypothesis that the fungi deter aphids via modifying plant volatile profiles. Next, we tested the hypothesis that endophytic colonization negatively affects aphid life history traits, such as fecundity, development and mortality rate. Aphids were significantly attracted to the odor of plants inoculated with A. muscarius over non-inoculated plants. Plants inoculated with A. muscarius emitted significantly higher amounts of β-pinene than non-inoculated plants, and significantly higher amounts of indole than B. bassiana-inoculated and non-inoculated plants. Inoculation with the fungal strains also caused significantly higher emission of terpinolene. Further, both aphid longevity and fecundity were significantly reduced by 18% and 10%, respectively, when feeding on plants inoculated with A. muscarius, although intrinsic rate of population increase did not differ between inoculated and non-inoculated plants. Sweet pepper plants inoculated with B. bassiana ARSEF 3097 did not elicit a significant behavioral response nor affected the investigated life history traits. We conclude that endophytic colonization by entomopathogenic fungi has the potential to alter olfactory behavior and performance of M. persicae var. nicotianae, but effects are small and depend on the fungal strain used

Enfoque para o manejo de resíduos não perigosos aproveitáveis, empregando uma estação ecológica

Introduction: This article is the result of the research project “Ecological Station based on renewable energies” currently developed by the Research Group on Technology and environment (gita) of the Corporación Universitaria Autónoma del Cauca and funded by the Human Talent Education Network Project for Social and Productive Innovation in the department of Cauca (InnovAcción Cauca), for a period of one year (September 2015 to 2016, the same month). Methodology: A review of the literature regarding the management of usable non-hazardous waste RnPA) is made, and includes technological trends and Management strategies. Additionally, a comparison is made based on the objectives of environmental education and major gaps and voids present when handling RnPA. Results: the architecture of an eco-friendly station (eco-station) as a pedagogical strategy, which integrates different forms of learning into the management RnPA during the collection stage.  Conclusions: material detection systems, user interaction, selection of waste and renewable energy supply within the eco-station streamline the learning process in the management and collection of RnPA at the source.Introducción: este artículo es producto del proyecto de investigación “Estación ecológica con base en energías renovables”, desarrollado actualmente por el Grupo de Investigación en Tecnología y Ambiente (GITA) de la Corporación Universitaria Autónoma del Cauca y financiado por el Proyecto Red de Formación de Talento Humano para la Innovación Social y Productiva en el departamento del Cauca (InnovAcción Cauca), por un periodo de un año (de septiembre del 2015 al 2016, del mismo mes). Metodología: se realiza una revisión de la literatura en relación con el manejo de residuos no peligrosos aprovechables (RnPA), presentando las tendencias tecnológicas y estrategias de manejo. Adicionalmente, se realiza una comparativa con base en los objetivos de la educación ambiental y se presentan las principales brechas y vacíos en el proceso de manejo de los RnPA. Resultados: la arquitectura de una estación ecológica-amigable (eco-estación) como estrategia pedagógica, donde se integran distintas formas de aprendizaje en el manejo de RnPA para su etapa de recolección. Conclusiones: los sistemas de detección de materiales, de interacción de usuario, de selección de residuos y de alimentación energética renovable en el interior de la eco-estación dinamizan el proceso de aprendizaje en el manejo y recolección en la fuente de RnPA.Introdução: este artigo é o resultado do projeto de investigação “Estação ecológica com base em energias renováveis”, desenvolvido atualmente pelo Grupo de Investigação em Tecnologia e Ambiente (gita) da Corporação Universitária Autónoma do Cauca e financiado pelo Projeto Rede de Formação de Talento Humano para a Inovação Social e Produtiva no departamento do Cauca (Inovação Cauca), por um período de um ano (de setembro de 2015 a 2016, do mesmo mês). Metodologia: é feita uma revisão da literatura no que tange o manejo de resíduos não perigosos aproveitáveis (RnPA), apresentando as tendências tecnológicas e estratégias de manejo. Adicionalmente, realiza-se uma comparação baseada nos objetivos da educação ambiental e apresentam-se os principais gaps e vazios no processo de manejo dos RnPA. Resultados: a arquitetura de uma estação ecológica-amigável (eco-estação) como estratégia pedagógica, onde se integram diversas formas de aprendizagem no manejo de RnPA para sua fase de coleta. Conclusões: os sistemas de detecção de materiais, de interação de usuário, de seleção de resíduos e de alimentação energética renovável no interior da eco-estação dinamizam o processo de aprendizado no manejo e coleta na fonte de RnPA

Expanded parameters to assess the quality of honey from Venezuelan bees (Apis mellifera).

Hive samples from seven Venezuelan states were studied to determine the quality of honeys from the naturalized tropical honey bee Apis mellifera, submitted for a national honey competition. The physicochemical composition varied as follows: antibacterial activity as minimal inhibitory concentration for each of S. aureus and E. coli was 25.0-50.0 g/100 mL, antioxidant activity was 34.90-203.21 ?moles Trolox equivalents/100 g, ash was 0.03-0.13 g/100 g, diastase activity was 3.00-47.81 DN, flavonoids was 2.32-14.41 mg EQ/100 g, free acidity was 24.40-54.55 meq/kg, HMF was 17.70-631.73 mg/kg, moisture content was 17.2-20.2 g/100 g and nitrogen was 28.68-107.29 mg/100 g. Non aromatic organic acids, such as D-gluconic acid, was 13.5-69.3 g/kg, citric acid was 8.0-135.4 mg/kg, and malic acid was 11.2-60.9 mg/kg. Polyphenols were 38.15-182.10 mg EGA/100g, reducing sugars were 62.05-77.57 g/100 g, sucrose was 0.93-13.86 g/100 g, and vitamin C was 12.86-37.05 mg/100 g. Botanical origins of the nine honeys, determined by pollen analysis, indicate that these honeys often were derived from non-forest, non-native and weedy species. The results are a first step to better characterisation of honeys, and some of the parameters were determined for the first time in Venezuelan A. mellifera honey. They can be used for research, educational purposes, and to better understand market values, natural occurrence and chemistry of tropical honey harvested from Apis mellifera

SF3B1, RUNX1 and TP53 Mutations Significantly Impact the Outcome of Patients With Lower-Risk Myelodysplastic Syndrome

[Introduction] Prognosis of patients with myelodysplastic syndrome (MDS), particularly the group with lower-risk disease (LR-MDS) is very heterogeneous. Several studies have described the prognostic value of recurrent somatic mutations in MDS including all risk categories. Recently, the incorporation of genomic data to clinical parameters defined the new Molecular International Prognostic Scoring System (IPSS-M).[Materials and Methods] In this study, we evaluated the impact of molecular profile in a series of 181 patients with LR-MDS and non-proliferative chronic myelomonocytic leukemia.[Results] Epigenetic regulators (TET2, ASXL1) and splicing (SF3B1) were the most recurrent mutated pathways. In univariate analysis, RUNX1 or TP53 mutations correlated with lower median overall survival (OS). In contrast, SF3B1 mutation was associated with prolonged median OS [95 months (95% IC, 32-157) vs. 33 months (95% CI, 19-46) in unmutated patients (P < 0.01)]. In a multivariate Cox regression model, RUNX1 mutations independently associated with shorter OS, while SF3B1 mutation retained its favorable impact on outcome (HR: 0.24, 95% CI, 0.1-0.5; P = 0.001). In addition, TP53 or RUNX1 mutations were identified as predictive covariates for the probability of leukemic progression (P < 0.001).[Conclusion] Incorporation of molecular testing in LR-MDS identified a subset of patients with expected poorer outcome, either due to lower survival or probability of leukemic progression.Peer reviewe

Effect of ultrapure lipopolysaccharides derived from diverse bacterial species on the modulation of platelet activation

Platelets are small circulating blood cells that play essential roles in the maintenance of haemostasis via blood clotting. However, they also play critical roles in the regulation of innate immune responses. Inflammatory receptors, specifically Toll-like receptor (TLR)-4, have been reported to modify platelet reactivity. A plethora of studies have reported controversial functions of TLR4 in the modulation of platelet function using various chemotypes and preparations of its ligand, lipopolysaccharide (LPS). The method of preparation of LPS may explain these discrepancies however this is not fully understood. Hence, to determine the impact of LPS on platelet activation, we used ultrapure preparations of LPS from Escherichia coli (LPSEC), Salmonella minnesota (LPSSM), and Rhodobacter sphaeroides (LPSRS) and examined their actions under diverse experimental conditions in human platelets. LPSEC did not affect platelet activation markers such as inside-out signalling to integrin IIb3 or P-selectin exposure upon agonist-induced activation in platelet-rich plasma or whole blood whereas LPSSM and LPSRS inhibited platelet activation under specific conditions at supraphysiological concentrations. Overall, our data demonstrate that platelet activation is not largely influenced by any of the ultrapure LPS chemotypes used in this study on their own except under certain conditions

Ruxolitinib in refractory acute and chronic graft-versus-host disease : a multicenter survey study

Graft-versus-host disease is the main cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. First-line treatment is based on the use of high doses of corticosteroids. Unfortunately, second-line treatment for both acute and chronic graft-versus-host disease, remains a challenge. Ruxolitinib has been shown as an effective and safe treatment option for these patients. Seventy-nine patients received ruxolitinib and were evaluated in this retrospective and multicenter study. Twenty-three patients received ruxolitinib for refractory acute graft-versus-host disease after a median of 3 (range 1-5) previous lines of therapy. Overall response rate was 69.5% (16/23) which was obtained after a median of 2 weeks of treatment, and 21.7% (5/23) reached complete remission. Fifty-six patients were evaluated for refractory chronic graft-versus-host disease. The median number of previous lines of therapy was 3 (range 1-10). Overall response rate was 57.1% (32/56) with 3.5% (2/56) obtaining complete remission after a median of 4 weeks. Tapering of corticosteroids was possible in both acute (17/23, 73%) and chronic graft-versus-host disease (32/56, 57.1%) groups. Overall survival was 47% (CI: 23-67%) at 6 months for patients with aGVHD (62 vs 28% in responders vs non-responders) and 81% (CI: 63-89%) at 1 year for patients with cGVHD (83 vs 76% in responders vs non-responders). Ruxolitinib in the real life setting is an effective and safe treatment option for GVHD, with an ORR of 69.5% and 57.1% for refractory acute and chronic graft-versus-host disease, respectively, in heavily pretreated patients